This is by no means the best photo of the Andromeda Galaxy (Messier 31), but this is pretty significant to me as this is my first good shot of a galaxy. It is easily visible to the naked eye at magnitude 3.4. In this photo, I had my lens at 55mm. In the below photo, it is seen at 18mm.
I tracked both photos manually on my German equatorial mount; the 55mm focal length was a little more challenging, since little errors show up more with more focal length. M31 is the brightest galaxy, and is probably the most photographed one, but I still like my first.